April 11, 2025

Medically Reviewed by By Girish Desai, the Chief Pharmacist at Landys Chemist since 1982

Written by Rhysa Phommachanh Head of Digital Marketing

Is NMN safe? Everything You Need to Know

Nicotinamide Mononucleotide (NMN) has gained popularity for its potential to improve energy levels and its anti-aging benefits. However, as with any supplement, it’s important to understand both the benefits and any potential risks. In this blog, we’ll explore common concerns about NMN’s safety, its efects, and whether it’s suitable for everyday use.

NMN safety concerns

What is NMN?

NMN is a naturally occurring compound that is involved in the production of nicotinamide adenine dinucleotide (NAD+), a molecule crucial for energy metabolism, DNA repair, and cell function. As we age, NAD+ levels decrease, which has sparked interest in NMN as a supplement to boost NAD+ levels and counteract the effects of ageing. Learn more about combining both NMN and NAD+ together here.

What Are the Negative Side Effects of NMN?

For most people, NMN is safe when taken in recommended doses. However, some users may experience mild side effects, such as:

Digestive discomfort: Some users report bloating or mild stomach upset.
Headaches: Headaches may occur in certain individuals as their body adjusts to the supplement.
Insomnia: Rarely, NMN can cause difficulty sleeping if taken too late in the day.

It is important to note that these side effects are not common and typically occur in people who are more sensitive to supplements. As Neesha Desai, Pharmacist at Landys Chemist, advises, "If you experience any persistent side effects, it's essential to stop NMN supplementation and consult a healthcare professional."

Is It Safe to Take NMN Daily?

Yes, NMN is generally safe for daily use. Research on NMN supplementation has shown that doses of 250mg to 500mg per day are typically well tolerated. As with any new supplement, it’s a good idea to start with a lower dose to see how your body responds.

Controversy with NMN and Cancer

There is some controversy surrounding NMN supplements due to its long-term safety. Most studies have been conducted on animals, and although some human trials, such as one published in 2021, show short-term benefits like improved insulin sensitivity, long-term effects are still unclear.

Health experts remain cautious due to the lack of extensive human trials, and there are concerns about the potential risks of prolonged use, such as impacts on cancer cell growth, as some studies suggest cancer cells might rely on higher NAD+ levels for their growth and survival. As Neesha Desai, Pharmacist at Landy’s Chemist, highlights, "More long-term human studies are needed to fully understand the safety of NMN."

Is NMN Safe in the UK?

In the UK, NMN is classified as a food supplement and is legal to buy and use. It’s not considered a controlled substance. However, Neesha Desai points out, "It’s always crucial to buy supplements from reputable sources to ensure the product’s quality and safety. Explore the Best NMN Supplements Available

Is NMN Being Banned?

Currently, NMN is not banned in the UK, although there have been regulatory concerns in the United States, with the FDA questioning its status as a dietary supplement. It’s important to stay up to date on any changes in legislation around supplements like NMN.

Does NMN Damage the Liver?

There is no evidence to suggest that NMN causes liver damage when taken in the recommended amounts. However, as with any supplement, excessive use or use in individuals with pre-existing liver conditions should be approached with caution.

At What Age Should You Take NMN?

NMN is typically considered beneficial for individuals over the age of 30 when natural NAD+ levels begin to decline. However, the exact age at which to start NMN supplementation depends on individual health goals.

Conclusion

NMN is generally safe for most individuals when used as directed, offering a range of health benefits, such as supporting energy levels and promoting healthy ageing. At Landys Chemist, most of our customers love NMN and have reported no significant issues when taking it as recommended. NMN is safe for most people, but responsible use and professional guidance are important to ensure the best results.

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This article is for informational purposes only and is not a substitute for medical advice. Consult your doctor or healthcare provider before starting any supplements, treatments, or remedies. Ensure a varied and balanced diet and a healthy lifestyle before considering supplements. Supplements should not replace a balanced diet.