Best Natural GLP-1 Activating Supplements
In recent years, Glucagon-Like Peptide-1 (GLP-1) receptor agonists like semaglutide (brand name Ozempic), Mounjaro (tirzepatide), and liraglutide have become popular treatments for managing type 2 diabetes, blood sugar control, and weight management.
However, with the rising demand for natural alternatives to these medications, people are increasingly turning to natural GLP-1 activating supplements along with other natural methods. You might seek these alternatives due to concerns over side effects and a desire for a more holistic approach. These natural options can offer similar effects to GLP-1 activators such as, supporting metabolism, helping to regulate hunger, and promoting a balanced blood sugar response, making them an appealing choice for those aiming to manage diabetes, obesity, or weight.
What is GLP-1?
GLP-1 is a hormone produced in the gut that plays a critical role in blood sugar regulation, appetite control, and overall metabolic health. This hormone helps to enhance insulin release and suppress glucagon (a hormone that raises blood sugar), preventing blood sugar spikes after meals. Additionally, it slows gastric emptying, making you feel fuller for longer—a benefit for weight management and weight loss.
Why do people take GLP-1 agonists like semaglutide?
GLP-1 agonists, such as semaglutide (marketed as Ozempic) and liraglutide, are primarily prescribed for individuals with type 2 diabetes or obesity to help manage blood sugar levels, control appetite, and improve metabolic health. For people with type 2 diabetes, these medications can be essential, as they help regulate blood sugar and reduce the risk of complications related to high blood glucose. For those with obesity, GLP-1 agonists can support weight loss efforts and reduce the risk of weight-related conditions.
However, while these medications can be effective for weight loss, they are not typically prescribed for individuals without diabetes or obesity who simply want to lose weight.
Additionally, they often come with side effects such as:
- Nausea, vomiting, and digestive discomfort
- Diarrhoea or constipation
- Fatigue or headaches
- Potential for low blood sugar (hypoglycemia) when used with other diabetes medications
The Best Natural GLP-1 Activating Supplements
For those interested in a more holistic approach, several natural supplements offer GLP-1 activating properties with benefits for blood sugar control, appetite regulation, and weight management. Recommended by us and backed by scientific research, here are the top five natural GLP-1 supplements to consider as an alternative:
1. Berberine:
Berberine is a plant compound popularly known for its ability to regulate blood sugar and enhance metabolism. Research indicates that berberine indirectly activates AMPK, an enzyme that improves insulin sensitivity and stimulates GLP-1 secretion, supporting both blood sugar balance and appetite control. A 2022 review of 18 studies on berberine’s effects on weight and 23 studies on BMI showed significant reductions in both weight and BMI, primarily among people taking more than 1 gram daily (1,000mg) for over 8 weeks. To obtain this effective dosage we recommend Coyne’s Bio-Berberine Complex capsules.
Studies also show a link between berberine supplementation and other weight management factors, such as improved gut microbiota diversity, reduced glucose and cholesterol absorption, and inhibited fat cell formation.
2. Curcumin
Curcumin, the active compound in turmeric, has powerful anti-inflammatory and antioxidant properties, which can also work as a natural GLP-1 activatior. Research shows that curcumin can improve insulin sensitivity and reduce blood sugar levels, aiding in the management of diabetes and weight.
Studies indicate that curcumin may activate pathways like AMPK which plays an important role in energy regulation and glucose metabolism, helping to stimulate GLP-1 secretion. A review of curcumin studies demonstrated its potential to enhance gut health, reduce cholesterol absorption, and inhibit fat accumulation, all of which can contribute to weight management. If you’re on the search we recommend Coyne Healthcare Bio-Curcumin Capsules, a more affordable alternative would be Nature's Plus Source of Life Garden Curcumin Capsules.
3. Probiotics:
Specific probiotic strains, especially Lactobacillus and Bifidobacterium, have been found to support GLP-1 activation by positively influencing gut microbiota balance. The enhancement of GLP-1 secretion through a balanced gut microbiota may aid in blood sugar control, appetite regulation, and weight management, all of which are crucial for managing type 2 diabetes and obesity.
Research shows that synbiotic and probiotic supplements may also improve insulin sensitivity, lower gut inflammation, reduce cholesterol, and limit fat storage, contributing to effective weight loss and metabolic health. Taking probiotics with resveratrol may also enhance GLP-1 secretion, improve glucose tolerance, and support insulin release, offering additional benefits for blood sugar control and gut health in managing type 2 diabetes. If you’re looking for a powerful probiotic we recommend Living Nutrition’s Organic Fermented Symbiotic Capsules. Due to its unique fermentation process, this symbiotic contains carefully selected strains linked to GLP-1 activation.. It’s also rich in phytonutrients, enzymes, peptides, and polyphenols, enhancing bioavailability and effectiveness for metabolic and digestive support
4. Green Tea Extract:
Green tea extract, particularly high in epigallocatechin gallate (EGCG), has shown potential in enhancing GLP-1 secretion and supporting metabolic health. Studies indicate that the combination of EGCG and caffeine from green tea may boost GLP-1 levels, inhibit gastric motility, and promote feelings of fullness by stimulating the satiety centre in the brain. These actions can support appetite regulation and weight management, which are beneficial for those with type 2 diabetes and obesity. Additionally, researchers observed that both undigested and digested green tea and turmeric extracts stimulated the release of satiety hormones, cholecystokinin (CCK) and GLP-1 in cells. Terranova’s Turmeric & Matcha Green Tea Capsules combines the benefits of turmeric and matcha, providing a potent source of EGCG and curcumin to support GLP-1 activation.
Can You Take These Natural Supplements with GLP-1 Agonist Medications?
If you're currently taking a GLP-1 agonist medication like semaglutide or mounjaro, natural supplements like berberine, curcumin, probiotics, and green tea extract may complement them. However, since these supplements can also affect blood sugar levels and metabolic pathways, it’s essential to consult a healthcare provider before adding them to your regimen. This guidance is particularly important to avoid potential interactions or additive effects when combining these natural supplements with GLP-1 agonists.
Conclusion
Natural GLP-1 activating supplements like berberine, curcumin, probiotics, and green tea extract provide promising options for supporting blood sugar regulation, appetite control, and metabolic health.
While these supplements may offer similar benefits to GLP-1 agonist medications like semaglutide, they tend to have fewer and milder side effects than these medications, which are often associated with nausea, digestive discomfort, and other issues.
For those seeking a more holistic approach to managing type 2 diabetes, weight, and metabolism, these natural supplements can be valuable, either on their own or as a complement to GLP-1 medications. It is also important to be mindful of the diet and lifestyle changes that can support your journey.
However, if you are already taking GLP-1 medications, consulting with a healthcare provider is essential to ensure safe integration and avoid potential interactions.
References:
- https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.1015045/full
- https://www.sciencedirect.com/science/article/abs/pii/S0041008X16303957
- https://www.nccih.nih.gov/health/berberine-and-weight-loss-what-you-need-to-know
- https://www.sciencedirect.com/science/article/pii/S0753332220303292
- https://www.sciencedirect.com/science/article/abs/pii/S0006291X13007468
- https://pmc.ncbi.nlm.nih.gov/articles/PMC4338652/
- https://www.sciencedirect.com/science/article/pii/S1347861319302609
- https://pmc.ncbi.nlm.nih.gov/articles/PMC8775659/
- https://www.sciencedirect.com/science/article/pii/S1756464619305882
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10790698/
- https://pubmed.ncbi.nlm.nih.gov/29931423/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC8091914/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10346988/
- https://europepmc.org/article/MED/3022652
